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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:83766
Term: olaparib
Definition: A member of the class of N-acylpiperazines obtained by formal condensation of the carboxy group of 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acid with the free amino group of N-(cyclpropylcarbonyl)piperazine; used to treat advanced ovarian cancer.
Chemical ID: MESH:C531550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1decreases bindingISOPARP1 (Homo sapiens)151356754RGDolaparib decreases binding of PARP1 to Cp promoter region in human lymphoblastoid cell lines 
Parp1decreases activityISOPARP1 (Homo sapiens)6480464CTDolaparib results in decreased activity of PARP1 proteinPMID:28001384
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDolaparib results in increased cleavage of PARP1 proteinPMID:29567272
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD(+)-JQ1 compound promotes the reaction [olaparib results in increased cleavage of PARP1 protein]; [BRD4 protein affects the susceptibility to olaparib] which affects the cleavage of PARP1 protein; INCB054329 promotes the reaction [olaparib results in increased cleavage of PARP1 protein]; olaparib inhibits the reaction [Methylmercury Compounds results in increased cleavage of PARP1 protein]; olaparib promotes the reaction [INCB054329 results in increased cleavage of PARP1 protein]PMID:29567272 PMID:35396826
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTDolaparib inhibits the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein]PMID:24814482
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