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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:7936
Term: paroxetine
Definition: A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
Chemical ID: MESH:D017374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDParoxetine results in decreased expression of STAT3 mRNA; Paroxetine results in decreased expression of STAT3 proteinPMID:17499975
Stat3increases expressionISOSTAT3 (Homo sapiens)6480464CTDParoxetine results in increased expression of STAT3 mRNAPMID:32020710
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDLY 215840 promotes the reaction [Paroxetine results in increased expression of STAT3 mRNA]PMID:32020710
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