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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731645
Species: Mus musculus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1multiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RPS6KB1 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; dorsomorphin inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]PMID:29859833 PMID:30248417 PMID:31982503
Rps6kb1multiple interactionsISORps6kb1 (Rattus norvegicus)6480464CTDdorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]PMID:28041982
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTDdorsomorphin inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] affects the phosphorylation of RPS6KB1 protein]; dorsomorphin inhibits the reaction [[Resveratrol results in increased abundance of Calcium] which results in decreased expression of RPS6KB1 protein modified form]; dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of RPS6KB1 protein]]PMID:23111315 PMID:23680031 PMID:31926917
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