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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11252
Species: Mus musculus
RGD Object: Gene
Symbol: S100b
Name: S100 protein, beta polypeptide, neural
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S100bincreases expressionEXP 6480464CTD1,2-Dimethylhydrazine results in increased expression of S100B mRNAPMID:22206623
S100bdecreases expressionISOS100b (Rattus norvegicus)6480464CTD1,2-Dimethylhydrazine results in decreased expression of S100B mRNAPMID:27840820
S100bmultiple interactionsISOS100b (Rattus norvegicus)6480464CTD[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of S100B mRNA; APC protein affects the reaction [1,2-Dimethylhydrazine results in decreased expression of S100B mRNA]PMID:27840820
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