GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tgfb1 | decreases expression | EXP | | 6480464 | CTD | platycodin D results in decreased expression of TGFB1 protein | PMID:29595072 | Tgfb1 | multiple interactions | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] | PMID:23603464 | Tgfb1 | multiple interactions | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of and results in increased secretion of IL17A protein]; platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of RORC protein]; platycodin D inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased phosphorylation of STAT3 protein]; platycodin D inhibits the reaction [TGFB1 protein results in decreased expression of and results in decreased secretion of IL10 protein]; platycodin D inhibits the reaction [TGFB1 protein results in decreased expression of FOXP3 protein] | PMID:25887267 | | ||||||||||||||||||||||
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