GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | decreases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | gambogic acid results in decreased expression of PARP1 mRNA | PMID:19084572 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | gambogic acid results in increased cleavage of PARP1 protein | PMID:19084572 PMID:19464570 PMID:24291039 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Bortezomib promotes the reaction [gambogic acid results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [gambogic acid promotes the reaction [Bortezomib results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; Bortezomib promotes the reaction [gambogic acid results in increased cleavage of PARP1 protein]; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of PARP1 mRNA]; Fluorouracil promotes the reaction [gambogic acid results in increased cleavage of PARP1 protein]; gambogic acid promotes the reaction [Bortezomib results in increased cleavage of PARP1 protein] | PMID:19084572 PMID:24291039 PMID:24373880 PMID:25824409 | | ||||||||||||||||||||||
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