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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68645
Species: Mus musculus
RGD Object: Gene
Symbol: Cldn5
Name: claudin 5
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn5multiple interactionsISOCldn5 (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [Hydrogen Sulfide results in decreased expression of CLDN5 protein]PMID:28741371 PMID:32404561
Cldn5multiple interactionsISOCLDN5 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dexamethasone inhibits the reaction [sodium bisulfide results in decreased expression of CLDN5 protein]]; Dexamethasone inhibits the reaction [[sodium bisulfide results in increased abundance of Hydrogen Sulfide] which results in decreased expression of CLDN5 protein]; Dexamethasone inhibits the reaction [sodium bisulfide results in decreased expression of CLDN5 protein]PMID:28741371 PMID:32404561
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