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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2063
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grk3
Name: G protein-coupled receptor kinase 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grk3decreases expressionISOGrk3 (Mus musculus)6480464CTDbisphenol A results in decreased expression of GRK3 mRNAPMID:32156529
Grk3decreases expressionISOGRK3 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GRK3 mRNAPMID:22576693
Grk3decreases methylationISOGrk3 (Mus musculus)6480464CTDbisphenol A results in decreased methylation of GRK3 promoterPMID:27312807
Grk3increases methylationISOGRK3 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of GRK3 genePMID:22576693 PMID:31601247
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