Gene: Grk3 (G protein-coupled receptor kinase 3) Rattus norvegicus
Symbol: Grk3
Name: G protein-coupled receptor kinase 3
Description: ENCODES a protein that exhibits beta-adrenergic receptor kinase activity; D1 dopamine receptor binding; G-protein coupled receptor kinase activity; INVOLVED IN desensitization of G-protein coupled receptor protein signaling pathway; inositol phosphate metabolic process; intracellular protein transport; PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH Cardiomegaly; Hypothyroidism; Parkinson Disease; FOUND IN axon; cilium; cytosol; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; cadmium dichloride
Type: protein-coding
Also known as: Adrbk2; Adrenergic receptor kinase beta 2 (G-protein-linked receptor kinase); adrenergic receptor kinase, beta 2; Adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase); adrenergic, beta, receptor kinase 2; beta ARK2; beta-adrenergic receptor kinase 2; beta-ARK-2; G-protein-coupled receptor kinase 3
Homo sapiens (human) : GRK3 (G protein-coupled receptor kinase 3)  HGNC  AGR
Mus musculus (house mouse) : Grk3 (G protein-coupled receptor kinase 3)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Grk3 (G protein-coupled receptor kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK3 (G protein-coupled receptor kinase 3)
Canis lupus familiaris (dog) : GRK3 (G protein-coupled receptor kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk3 (G protein-coupled receptor kinase 3)
more info ...
Is Marker For: Strains:   SHHF  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01249,626,871 - 49,750,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01251,433,367 - 51,510,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,261,279 - 45,319,394 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Grk3
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2063
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE