Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | GRK3 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
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Molecular Function
Molecular Pathway Annotations Click to see Annotation Detail View
RGD Manual Annotations
Imported Annotations - PID (archival)
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. | Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7. |
| 2. | The changes in beta-adrenoceptor-mediated cardiac function in experimental hypothyroidism: the possible contribution of cardiac beta3-adrenoceptors. | Arioglu E, etal., Mol Cell Biochem. 2010 Feb;335(1-2):59-66. Epub 2009 Sep 1. |
| 3. | The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. | Arriza JL, etal., J Neurosci 1992 Oct;12(10):4045-55. |
| 4. | The physiology, signaling, and pharmacology of dopamine receptors. | Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. |
| 5. | Gender differences in beta-adrenoceptor system in cardiac hypertrophy due to arteriovenous fistula. | Dent MR, etal., J Cell Physiol. 2011 Jan;226(1):181-6. |
| 6. | Prolonged Morphine Treatment Alters Expression and Plasma Membrane Distribution of ß-Adrenergic Receptors and Some Other Components of Their Signaling System in Rat Cerebral Cortex. | Hejnova L, etal., J Mol Neurosci. 2017 Dec;63(3-4):364-376. doi: 10.1007/s12031-017-0987-9. Epub 2017 Oct 28. |
| 7. | The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. | Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16. |
| 8. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 9. | MGD IEA | MGD IEA |
| 10. | beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases. | Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299. |
| 11. | Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables. | Montó F, etal., Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8. |
| 12. | G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. | Peppel K, etal., J Biol Chem. 1997 Oct 10;272(41):25425-8. |
| 13. | Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. | Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6. |
| 14. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 15. | Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients. | Rao JS, etal., Int J Neuropsychopharmacol. 2009 Jul;12(6):851-60. Epub 2009 Apr 29. |
| 16. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 17. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 18. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 19. | Angiotensin II-stimulated signaling through G proteins and beta-arrestin. | Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14. |
| 20. | Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. | Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30. |
| 21. | Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. | Álvaro-Bartolomé M and García-Sevilla JA, Neuroscience. 2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29. |
Additional References at PubMed
| PMID:1869533 | PMID:7761854 | PMID:8035170 | PMID:8638670 | PMID:8889548 | PMID:8917529 | PMID:8955126 | PMID:9345023 | PMID:9365243 | PMID:9802886 | PMID:10198406 | PMID:10338466 |
| PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12466851 | PMID:12794091 | PMID:14610273 | PMID:15140929 | PMID:16141072 | PMID:16141073 | PMID:16602821 |
| PMID:17344394 | PMID:17698926 | PMID:17959804 | PMID:18165681 | PMID:18554416 | PMID:20534436 | PMID:21267068 | PMID:21677750 | PMID:21873635 | PMID:23935208 | PMID:24629717 | PMID:28706196 |
| PMID:29166587 | PMID:30076211 | PMID:32325033 | PMID:34873237 | PMID:35093170 | PMID:36451830 | PMID:37048054 |
Genomics
Comparative Map Data
| Grk3 (Mus musculus - house mouse) |
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| GRK3 (Homo sapiens - human) |
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| Grk3 (Rattus norvegicus - Norway rat) |
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| Grk3 (Chinchilla lanigera - long-tailed chinchilla) |
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| GRK3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| GRK3 (Canis lupus familiaris - dog) |
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| Grk3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| GRK3 (Sus scrofa - pig) |
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| GRK3 (Chlorocebus sabaeus - green monkey) |
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| Grk3 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Grk3
3595 total Variants 
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