GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | decreases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of PARP1 mRNA; Benzo(a)pyrene results in decreased expression of PARP1 protein | PMID:20064835 PMID:33278487 | Parp1 | decreases expression | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of PARP1 mRNA | PMID:19770486 | Parp1 | decreases methylation | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of PARP1 exon; Benzo(a)pyrene results in decreased methylation of PARP1 intron | PMID:27901495 | Parp1 | decreases response to substance | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | PARP1 protein results in decreased susceptibility to Benzo(a)pyrene | PMID:19247804 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased cleavage of PARP1 protein | PMID:20840854 PMID:24685774 | Parp1 | increases cleavage | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased cleavage of PARP1 protein | PMID:19041363 PMID:32061149 | Parp1 | increases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of PARP1 protein | PMID:24664296 | Parp1 | increases methylation | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of PARP1 promoter | PMID:27901495 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | 2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein]; [[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PARP1 protein]; MCL1 protein affects the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; MCL1 protein inhibits the reaction [Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; MCL1 protein promotes the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; USP7 protein affects the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; Vitamin E inhibits the reaction [Benzo(a)pyrene results in increased expression of PARP1 protein]; Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein] | PMID:20840854 PMID:24664296 PMID:32802178 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene promotes the reaction [AHR protein binds to PARP1 promoter]; Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] | PMID:19654925 PMID:32061149 | | ||||||||||||||||||||||
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