GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | treatment | ISO | STAT3 (Homo sapiens) | 127284846 | RGD | N-acetyl-L-cysteine co-treated with Il-6 inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of STAT3 protein in the stomach) | | Stat3 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]] | PMID:21912612 | Stat3 | decreases phosphorylation | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Acetylcysteine results in decreased phosphorylation of STAT3 protein | PMID:29894800 | Stat3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of STAT3 mRNA]; Acetylcysteine inhibits the reaction [NSC 680410 results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased methylation of STAT3 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein] | PMID:16481037 PMID:23948867 PMID:28739487 PMID:29329563 PMID:34425375 | Stat3 | multiple interactions | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Acetylcysteine inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STAT3 protein modified form]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STAT3 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of and results in increased expression of STAT3 protein]; Acetylcysteine inhibits the reaction [manumycin results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein] | PMID:16896058 PMID:17666914 PMID:19409983 PMID:21741372 PMID:24582688 PMID:24820114 PMID:27856279 PMID:28284859 PMID:29329563 PMID:29894800 PMID:30871965 PMID:31433961 PMID:33030807 PMID:34627931 | | ||||||||||||||||||||||
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