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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkndecreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of PRKN mRNA; Doxorubicin results in decreased expression of PRKN proteinPMID:32434049
Prkndecreases response to substanceEXP 6480464CTDPRKN protein results in decreased susceptibility to DoxorubicinPMID:32434049
Prknincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of PRKN proteinPMID:26678157 PMID:29966675
Prknmultiple interactionsEXP 6480464CTDDoxorubicin inhibits the reaction [YAP1 protein binds to PRKN promoter]PMID:32434049
Prkndecreases expressionISOPrkn (Mus musculus)6480464CTDDoxorubicin results in decreased expression of PRKN proteinPMID:32434049
Prkndecreases expressionISOPRKN (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of PRKN mRNAPMID:29803840
Prknincreases expressionISOPRKN (Homo sapiens)6480464CTDDoxorubicin results in increased expression of PRKN proteinPMID:29729358
Prknmultiple interactionsISOPrkn (Mus musculus)6480464CTDPRKN protein affects the reaction [Doxorubicin results in increased expression of MYH7 mRNA]; PRKN protein affects the reaction [Doxorubicin results in increased expression of NPPB mRNA]PMID:32434049
Prknmultiple interactionsISOPRKN (Homo sapiens)6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Doxorubicin results in increased expression of PRKN protein]; MitoTEMPO inhibits the reaction [Doxorubicin results in increased expression of PRKN protein]PMID:29729358
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