GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | AKT1 | increases activity | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased activity of AKT1 protein | PMID:16051281 | AKT1 | increases phosphorylation | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein | PMID:27312872 | AKT1 | multiple interactions | EXP | | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of AKT1 protein]; [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of AKT1 mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; EGFR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of AKT1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of AKT1 protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of AKT1 protein | PMID:11309286 PMID:12668121 PMID:21807014 PMID:27312872 PMID:29704546 | AKT1 | decreases phosphorylation | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased phosphorylation of AKT1 protein | PMID:23639626 | AKT1 | increases expression | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of AKT1 mRNA | PMID:34747641 | AKT1 | increases expression | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of AKT1 mRNA | PMID:17942748 | AKT1 | increases phosphorylation | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein | PMID:24231000 | AKT1 | increases phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein | PMID:28302560 | AKT1 | multiple interactions | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of AKT1 protein]; AHR mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; IGFBP4 mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of AKT1 protein] | PMID:23639626 PMID:24231000 | AKT1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKT1 mRNA | PMID:17942748 PMID:28302560 | | ||||||||||||||||||||||
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