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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CYP2E1 mRNAPMID:22298810
CYP2E1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP2E1; Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA; Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 proteinPMID:20106945 PMID:21296121 PMID:26159488 PMID:27055685 PMID:28571685 PMID:28673560
CYP2E1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP2E1 mRNAPMID:23669205
CYP2E1multiple interactionsEXP 6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]; [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP2E1 mRNA; AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]; ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]; Endosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Endosulfan results in decreased expression of CYP2E1 mRNA]PMID:26159488 PMID:28673560
CYP2E1affects expressionISOCyp2e1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CYP2E1 mRNAPMID:17949056
CYP2E1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNAPMID:19770486 PMID:28213091
CYP2E1decreases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA; Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 proteinPMID:16054898 PMID:18796159 PMID:19692669 PMID:21215274 PMID:31511937 PMID:32387183
CYP2E1increases expressionISOCyp2e1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP2E1 mRNAPMID:16120747
CYP2E1increases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP2E1 mRNAPMID:19969063
CYP2E1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP2E1 gene]PMID:28213091
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTD[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of CYP2E1 mRNAPMID:21602191
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