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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3multiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 mRNA]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 protein]PMID:23421680
Stat3affects activityISOSTAT3 (Homo sapiens)6480464CTDresveratrol affects the activity of STAT3 proteinPMID:25063218
Stat3affects localizationISOSTAT3 (Homo sapiens)6480464CTDresveratrol affects the localization of STAT3 proteinPMID:18592012 PMID:26911335 PMID:27064016
Stat3decreases acetylationISOSTAT3 (Homo sapiens)6480464CTDresveratrol results in decreased acetylation of STAT3 proteinPMID:23681230
Stat3decreases activityISOSTAT3 (Homo sapiens)6480464CTDresveratrol results in decreased activity of STAT3 proteinPMID:21503893 PMID:25061499
Stat3decreases expressionISOStat3 (Mus musculus)6480464CTDresveratrol results in decreased expression of STAT3 protein modified formPMID:19063842
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDresveratrol results in decreased expression of STAT3; resveratrol results in decreased expression of STAT3 mRNA; resveratrol results in decreased expression of STAT3 protein; resveratrol results in decreased expression of STAT3 protein modified formPMID:18592012 PMID:23372833 PMID:23681230 PMID:24064760 PMID:24587049 PMID:25061499 PMID:25896424 PMID:26432044
Stat3decreases phosphorylationISOStat3 (Mus musculus)6480464CTDresveratrol results in decreased phosphorylation of STAT3 proteinPMID:26138072
Stat3decreases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDresveratrol results in decreased phosphorylation of STAT3 proteinPMID:18592012 PMID:24090995 PMID:24627483 PMID:25351437 PMID:26138072 PMID:26432044
Stat3increases expressionISOStat3 (Mus musculus)6480464CTDresveratrol results in increased expression of STAT3 proteinPMID:25505154
Stat3increases phosphorylationISOStat3 (Mus musculus)6480464CTDresveratrol results in increased phosphorylation of STAT3 proteinPMID:21342247
Stat3increases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of STAT3 proteinPMID:22748497
Stat3increases response to substanceISOStat3 (Mus musculus)6480464CTDSTAT3 protein results in increased susceptibility to resveratrolPMID:21342247
Stat3multiple interactionsISOStat3 (Mus musculus)6480464CTDIL10 protein affects the reaction [Resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [APP protein results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Arginine results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of STAT3 protein]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased phosphorylation of and results in increased activity of STAT3 protein]; Resveratrol inhibits the reaction [Dietary Fats results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [LEP protein results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]; Resveratrol promotes the reaction [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in increased phosphorylation of STAT3 protein]]; Resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]; Resveratrol results in decreased activity of and results in decreased phosphorylation of STAT3 protein; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]PMID:19796711 PMID:20155626 PMID:22118570 PMID:25576658 PMID:25651848 PMID:26074695 PMID:26100520 PMID:31881177 PMID:34423886
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of STAT3 protein modified form]]; [Resveratrol co-treated with Bortezomib] results in decreased phosphorylation of STAT3 protein; [Resveratrol co-treated with nano-diamino-tetrac] results in decreased expression of and results in decreased phosphorylation of STAT3 protein; [Resveratrol co-treated with Thalidomide] results in decreased phosphorylation of STAT3 protein; NDUFA13 protein affects the reaction [Resveratrol results in decreased phosphorylation of STAT3 protein]; Panobinostat promotes the reaction [Resveratrol inhibits the reaction [STAT3 protein binds to GADD45G promoter]]; PTPRE protein affects the reaction [Resveratrol results in decreased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of STAT3 protein modified form]; Resveratrol inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [STAT3 protein binds to GADD45G promoter]; Resveratrol inhibits the reaction [STAT3 protein results in increased expression of BCL2L1 protein]; Resveratrol inhibits the reaction [STAT3 protein results in increased expression of CCND1 protein]; Resveratrol inhibits the reaction [STAT3 protein results in increased expression of MCL1 protein]; Resveratrol promotes the reaction [Sorafenib results in decreased phosphorylation of STAT3 protein]; Resveratrol results in decreased activity of and results in decreased phosphorylation of STAT3 protein; Resveratrol results in decreased expression of and affects the localization of STAT3 protein modified form; Resveratrol results in decreased expression of and results in decreased phosphorylation of STAT3 protein; Resveratrol results in decreased phosphorylation of and affects the localization of STAT3 protein; Resveratrol results in decreased phosphorylation of and results in decreased activity of STAT3 protein; Resveratrol results in decreased phosphorylation of and results in decreased expression of STAT3 protein; SIRT1 protein affects the reaction [Resveratrol results in decreased expression of STAT3 protein modified form]; SOCS1 protein affects the reaction [Resveratrol results in decreased phosphorylation of STAT3 protein]; Vanadates affects the reaction [Resveratrol results in decreased phosphorylation of STAT3 protein]; Vanadates inhibits the reaction [Resveratrol results in decreased phosphorylation of STAT3 protein]PMID:16546976 PMID:17164350 PMID:18222423 PMID:19796711 PMID:23681230 PMID:24064760 PMID:24587049 PMID:25351437 PMID:25896424 PMID:26911335 PMID:27064016 PMID:31883986
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