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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionEXP 6480464CTDResveratrol results in increased expression of GCLC mRNA; Resveratrol results in increased expression of GCLC proteinPMID:21520053 PMID:36584933
Gclcmultiple interactionsEXP 6480464CTDNFE2L2 protein affects the reaction [Resveratrol results in increased expression of GCLC protein]PMID:36584933
Gclcincreases expressionISOGclc (Rattus norvegicus)6480464CTDresveratrol results in increased expression of GCLC mRNAPMID:15882976
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTDresveratrol results in increased expression of GCLC mRNAPMID:11909699 PMID:20060927 PMID:20418481
Gclcmultiple interactionsISOGclc (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]; resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein]PMID:21439372
Gclcmultiple interactionsISOGCLC (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of GCLC mRNA]; [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Resveratrol] results in increased expression of GCLC mRNA; [Resveratrol results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; NFE2L2 protein affects the reaction [Resveratrol results in increased expression of GCLC mRNA]; Resveratrol inhibits the reaction [deoxynivalenol results in decreased expression of GCLC protein]; Resveratrol promotes the reaction [hydroquinone results in increased expression of GCLC mRNA]PMID:11909699 PMID:20418481 PMID:27818126 PMID:32334435 PMID:37419272
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