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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcdecreases expressionISOGclc (Rattus norvegicus)6480464CTDZinc deficiency results in decreased expression of GCLC mRNA; Zinc deficiency results in decreased expression of GCLC proteinPMID:23377617
Gclcdecreases expressionISOGCLC (Homo sapiens)6480464CTDZinc deficiency results in decreased expression of GCLC mRNAPMID:23377617
Gclcmultiple interactionsISOGCLC (Homo sapiens)6480464CTDacetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein]; Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of GCLC protein]; Zinc deficiency results in decreased expression of and results in increased cleavage of GCLC proteinPMID:23377617
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