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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:25351
Term: mevalonic acid
Definition: A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.
Chemical ID: MESH:D008798
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3multiple interactionsEXP 6480464CTDMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]]PMID:16534557
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDMevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT3 protein]PMID:18453621
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