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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737013
Species: Homo sapiens
RGD Object: Gene
Symbol: TLR4
Name: toll like receptor 4
Acc ID: CHEBI:44915
Term: propofol
Definition: A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Chemical ID: MESH:D015742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TLR4multiple interactionsISOTlr4 (Mus musculus)6480464CTDPropofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]PMID:19433076
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