Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	736025
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	LDHA
Name:	lactate dehydrogenase A

Acc ID:	CHEBI:46195
Term:	paracetamol
Definition:	A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID:	MESH:D000082

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
LDHA	decreases activity	EXP		6480464	CTD	Acetaminophen results in decreased activity of LDHA protein	PMID:38042273
LDHA	decreases expression	EXP		6480464	CTD	Acetaminophen results in decreased expression of LDHA mRNA	PMID:11793227 PMID:29067470
LDHA	multiple interactions	EXP		6480464	CTD	acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Acetaminophen results in decreased activity of LDHA protein]; Fomepizole inhibits the reaction [Acetaminophen results in decreased activity of LDHA protein]; ursodoxicoltaurine inhibits the reaction [Acetaminophen results in decreased activity of LDHA protein]	PMID:38042273
LDHA	affects expression	ISO	Ldha (Mus musculus)	6480464	CTD	Acetaminophen affects the expression of LDHA mRNA	PMID:17562736
LDHA	decreases expression	ISO	Ldha (Rattus norvegicus)	6480464	CTD	Acetaminophen results in decreased expression of LDHA mRNA	PMID:33387578
LDHA	multiple interactions	ISO	Ldha (Mus musculus)	6480464	CTD	[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of LDHA protein	PMID:25499718

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