Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	735138
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tlr2
Name:	toll-like receptor 2

Acc ID:	DOID:850
Term:	lung disease
Definition:	A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. (DO)
Definition Source(s):	http://www.niehs.nih.gov/health/topics/conditions/lung-disease/index.cfm "DO" "DO", http://www.nlm.nih.gov/medlineplus/ency/article/000066.htm "DO" "DO"

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tlr2		IDA		2312725	RGD	associated with Pancreatitis, Acute Necrotizing
Tlr2		IEP		4145303	RGD	Acute Lung Injury;mRNA:increased expression:lung
Tlr2		IEP		4145321	RGD	associated with Hyperoxia;mRNA, protein:increased expression:lung
Tlr2		ISO	TLR2 (Homo sapiens)	4145340	RGD	associated with Mycobacterium avium-intracellulare Infection;DNA:polymorphism:intron (human)

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