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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732968
Species: Homo sapiens
RGD Object: Gene
Symbol: XRCC1
Name: X-ray repair cross complementing 1
Acc ID: CHEBI:61076
Term: belinostat
Definition: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Chemical ID: MESH:C487081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
XRCC1decreases expressionISOXrcc1 (Mus musculus)6480464CTDbelinostat results in decreased expression of XRCC1 mRNA; belinostat results in decreased expression of XRCC1 proteinPMID:29733868
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