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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732968
Species: Homo sapiens
RGD Object: Gene
Symbol: XRCC1
Name: X-ray repair cross complementing 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
XRCC1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of XRCC1 mRNAPMID:12634122
XRCC1multiple interactionsEXP 6480464CTD[EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of XRCC1 mRNA; [EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of XRCC1 protein; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of XRCC1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of XRCC1 protein; BIX 01294 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of XRCC1 mRNA]; BIX 01294 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of XRCC1 protein]; Ginkgo biloba extract inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of XRCC1 mRNA]; Ginkgo biloba extract inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of XRCC1 protein]PMID:33378118
XRCC1decreases expressionISOXrcc1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of XRCC1 mRNAPMID:16014739
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