GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Alpl | increases activity | EXP | | 6480464 | CTD | Tretinoin results in increased activity of ALPL protein | PMID:10567916 | Alpl | increases expression | EXP | | 6480464 | CTD | Tretinoin results in increased expression of ALPL mRNA; Tretinoin results in increased expression of ALPL protein | PMID:10704935 PMID:16604517 | Alpl | multiple interactions | EXP | | 6480464 | CTD | AGN 193109 inhibits the reaction [Indinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]]; Indinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]; Tretinoin results in increased expression of and results in increased N-linked glycosylation of ALPL protein; Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein] | PMID:10567916 PMID:10704935 | Alpl | decreases expression | ISO | ALPL (Homo sapiens) | 6480464 | CTD | Tretinoin results in decreased expression of ALPL mRNA | PMID:21934132 | Alpl | increases activity | ISO | ALPL (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased activity of ALPL protein | PMID:10567916 | Alpl | increases activity | ISO | Alpl (Rattus norvegicus) | 6480464 | CTD | Tretinoin results in increased activity of ALPL protein | PMID:10567916 PMID:11171635 | Alpl | increases expression | ISO | Alpl (Rattus norvegicus) | 6480464 | CTD | Tretinoin results in increased expression of ALPL mRNA | PMID:10022522 PMID:10567916 | Alpl | multiple interactions | ISO | ALPL (Homo sapiens) | 6480464 | CTD | Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]; Tretinoin inhibits the reaction [Tunicamycin results in increased degradation of ALPL protein]; Tretinoin results in increased expression of and results in increased N-linked glycosylation of ALPL protein; Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein] | PMID:10567916 | Alpl | multiple interactions | ISO | Alpl (Rattus norvegicus) | 6480464 | CTD | EGF protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]; IL1B protein promotes the reaction [Tretinoin results in increased expression of ALPL mRNA]; IL1B protein promotes the reaction [Tretinoin results in increased expression of and results in increased activity of ALPL protein]; IL2 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]; IL4 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]; IL5RA protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]; Tretinoin results in increased expression of and results in increased N-linked glycosylation of ALPL protein; Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein] | PMID:10567916 PMID:11171635 | | ||||||||||||||||||||||
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