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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731579
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGCR
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:76591
Term: (25R)-cholest-5-ene-3beta,26-diol
Definition: A 26-hydroxycholesterol in which the 25-position has R-configuration.
Chemical ID: MESH:C076996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGCRdecreases activityEXP 6480464CTD27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein; 27-hydroxycholesterol results in decreased activity of HMGCR proteinPMID:18024962 PMID:7749852 PMID:7751816 PMID:9059514
HMGCRmultiple interactionsEXP 6480464CTD[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]PMID:11408283 PMID:9059514
HMGCRdecreases activityISOHmgcr (Rattus norvegicus)6480464CTD27-hydroxycholesterol results in decreased activity of HMGCR proteinPMID:7749852 PMID:7788503
HMGCRdecreases expressionISOHmgcr (Rattus norvegicus)6480464CTD27-hydroxycholesterol results in decreased expression of HMGCR mRNA; 27-hydroxycholesterol results in decreased expression of HMGCR proteinPMID:28167099
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