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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1increases expressionEXP 6480464CTDDexamethasone results in increased expression of HMOX1 mRNAPMID:19853017
HMOX1multiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HMOX1 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMOX1 mRNA; Dexamethasone inhibits the reaction [TNF protein results in increased expression of HMOX1 mRNA]PMID:21420233 PMID:28628672
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDDexamethasone results in increased expression of HMOX1 proteinPMID:28940008
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of HMOX1 mRNAPMID:21986892
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTDCDKN1A protein affects the reaction [Dexamethasone results in increased expression of HMOX1 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Dexamethasone inhibits the reaction [Zymosan results in increased expression of HMOX1 protein]; Dexamethasone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]PMID:11454666 PMID:26363199 PMID:28940008 PMID:30849337
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA; [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein; Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA]; Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]; Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]; Hydrogen Peroxide affects the reaction [Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]]; Hydrogen Peroxide affects the reaction [Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]]; Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA]; Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]; Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]; Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]]PMID:21986892 PMID:27028516
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