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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3increases expressionISOEIF2AK3 (Homo sapiens)6480464CTDhydroquinone results in increased expression of EIF2AK3 proteinPMID:36646296
Eif2ak3increases phosphorylationISOEIF2AK3 (Homo sapiens)6480464CTDhydroquinone results in increased phosphorylation of EIF2AK3 proteinPMID:24053669
Eif2ak3multiple interactionsISOEIF2AK3 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased expression of EIF2AK3 protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of EIF2AK3 protein]PMID:36646296
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