GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | decreases activity | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Mifepristone results in decreased activity of CYP3A4 protein | PMID:15860655 PMID:16049126 PMID:22652334 | Cyp3a2 | increases expression | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Mifepristone results in increased expression of CYP3A4 mRNA | PMID:12235278 PMID:15466163 PMID:16837568 | Cyp3a2 | multiple interactions | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | [Mifepristone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Mifepristone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Mifepristone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Mifepristone inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Mifepristone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Mifepristone inhibits the reaction [NR3C1 protein promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA]]; NR1I2 protein promotes the reaction [Mifepristone results in increased expression of CYP3A4 mRNA] | PMID:10219967 PMID:12235278 PMID:16049126 PMID:17041008 PMID:19299527 PMID:22652334 | | ||||||||||||||||||||||
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