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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1affects expressionISOSREBF1 (Homo sapiens)6480464CTDValproic Acid affects the expression of SREBF1 mRNAPMID:25979313
Srebf1affects expressionISOSrebf1 (Mus musculus)6480464CTDValproic Acid affects the expression of SREBF1 mRNAPMID:17292431 PMID:17963808
Srebf1decreases expressionISOSREBF1 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of SREBF1 mRNAPMID:29154799
Srebf1increases expressionISOSREBF1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of SREBF1 mRNA; Valproic Acid results in increased expression of SREBF1 proteinPMID:25716160 PMID:27089845 PMID:30003287
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTDNR1H3 protein affects the reaction [Valproic Acid results in increased expression of SREBF1 mRNA]; NR1H3 protein promotes the reaction [Valproic Acid results in increased expression of SREBF1 mRNA]PMID:30003287
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