GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i2 | decreases expression | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | Ketoconazole results in decreased expression of NR1I2 mRNA; Ketoconazole results in decreased expression of NR1I2 protein | PMID:16608920 PMID:17998298 PMID:36893891 | Nr1i2 | decreases response to substance | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | NR1I2 protein mutant form results in decreased susceptibility to Ketoconazole | PMID:17438109 | Nr1i2 | increases activity | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | Ketoconazole results in increased activity of NR1I2 protein | PMID:25343516 PMID:25680588 | Nr1i2 | multiple interactions | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | [Ketoconazole co-treated with Rifampin] results in increased activity of NR1I2 protein; Ketoconazole binds to and results in decreased activity of NR1I2 protein; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin binds to and results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] | PMID:12072427 PMID:16608920 PMID:16819505 PMID:17438109 PMID:17998298 PMID:20869355 PMID:21402137 PMID:23525103 PMID:23707768 PMID:26616219 PMID:29356861 | Nr1i2 | multiple interactions | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] | PMID:16819505 | | ||||||||||||||||||||||
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