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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:3011
Term: benazepril
Definition: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
Chemical ID: MESH:C044946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1affects expressionEXP 6480464CTDbenazepril affects the expression of TGFB1 mRNAPMID:16635409
Tgfb1decreases expressionEXP 6480464CTDbenazepril results in decreased expression of TGFB1 mRNA; benazepril results in decreased expression of TGFB1 proteinPMID:11798627 PMID:11867951 PMID:16191423 PMID:17177138 PMID:19018797
Tgfb1multiple interactionsEXP 6480464CTD[benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; [benazepril co-treated with Irbesartan] affects the expression of TGFB1 mRNA; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]PMID:10515446 PMID:16409969 PMID:16523407 PMID:16635409 PMID:19487956 PMID:20493835 PMID:20844835
Tgfb1decreases expressionISOTGFB1 (Homo sapiens)6480464CTDbenazepril results in decreased expression of TGFB1 proteinPMID:18390891
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTD[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 proteinPMID:18390891
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