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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620525
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mcl1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mcl1affects expressionISOMCL1 (Homo sapiens)6480464CTDFluorouracil affects the expression of MCL1 proteinPMID:21036698
Mcl1decreases expressionISOMcl1 (Mus musculus)6480464CTDFluorouracil results in decreased expression of MCL1 mRNAPMID:28025107
Mcl1decreases response to substanceISOMCL1 (Homo sapiens)6480464CTDMCL1 protein results in decreased susceptibility to FluorouracilPMID:15262975
Mcl1multiple interactionsISOMcl1 (Mus musculus)6480464CTDApigenin promotes the reaction [Fluorouracil results in decreased expression of MCL1 mRNA]; Fluorouracil promotes the reaction [Apigenin results in decreased expression of MCL1 mRNA]PMID:28025107
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