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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfamultiple interactionsEXP 6480464CTDValsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]PMID:11897773 PMID:14638905 PMID:14718351
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDValsartan results in decreased expression of VEGFA mRNAPMID:22768174
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDValsartan results in decreased expression of VEGFA mRNAPMID:35235860
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTDFluorouracil promotes the reaction [Valsartan results in decreased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of VEGFA mRNA]PMID:17724226 PMID:35235860
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