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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619823
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xrcc1
Name: X-ray repair cross complementing 1
Acc ID: CHEBI:44215
Term: NAD zwitterion
Definition: A NAD that has formula C21H27N7O14P2.
Chemical ID: MESH:D009243
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xrcc1decreases reductionISOXrcc1 (Mus musculus)6480464CTDXRCC1 gene mutant form results in decreased reduction of NADPMID:30998386
Xrcc1multiple interactionsISOXRCC1 (Homo sapiens)6480464CTD[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD; olaparib affects the reaction [[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD]; veliparib affects the reaction [[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD]; XRCC1 protein affects the reaction [Hydrogen Peroxide results in decreased abundance of NAD]; XRCC1 protein affects the reaction [PARP1 protein affects the reaction [Hydrogen Peroxide results in decreased abundance of NAD]]PMID:35778544
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