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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases expressionEXP 6480464CTDCurcumin results in decreased expression of STAT3 mRNAPMID:25963729
Stat3multiple interactionsEXP 6480464CTDCurcumin analog inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of STAT3 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]PMID:25963729 PMID:30431687
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDCurcumin results in decreased expression of STAT3 mRNA; Curcumin results in decreased expression of STAT3 proteinPMID:16959222 PMID:20816778 PMID:36352148
Stat3decreases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDCurcumin results in decreased phosphorylation of STAT3 proteinPMID:19383353
Stat3increases phosphorylationISOStat3 (Mus musculus)6480464CTDCurcumin results in increased phosphorylation of STAT3 proteinPMID:25822711
Stat3multiple interactionsISOStat3 (Mus musculus)6480464CTD[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT3 protein]PMID:33617879
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [Curcumin results in decreased expression of STAT3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of STAT3 protein]PMID:16959222 PMID:17666914 PMID:19383353 PMID:34233590 PMID:36352148
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