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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:24650
Term: hydroxamic acid
Definition: A compound, RkE(=O)lNHOH, derived from an oxoacid RkE(=O)l(OH) (l =/= 0) by replacing -OH with -NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as N-hydroxy amides.
Chemical ID: MESH:D006877
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3multiple interactionsISOStat3 (Mus musculus)6480464CTDHydroxamic Acids analog inhibits the reaction [EGF protein promotes the reaction [STAT3 protein binds to EGFR protein]]; Hydroxamic Acids analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Hydroxamic Acids analog results in decreased phosphorylation of and results in decreased activity of STAT3 proteinPMID:26088127
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDHydroxamic Acids analog inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Hydroxamic Acids analog results in decreased phosphorylation of and results in decreased activity of STAT3 proteinPMID:26088127
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