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GENE - TERM ANNOTATION REPORT

RGD ID: 3001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: DOID:9007692
Term: Insulin Resistance
Definition: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Definition Source(s): MESH:D007333
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepr IAGP 13432147RGD  
Lepr ISOLEPR (Homo sapiens)2311138RGDassociated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.K656N (human) 
Lepr ISOLEPR (Homo sapiens)2311142RGDassociated with Obesity;DNA:polymorphism: :p.K656N (human) 
Lepr ISOLEPR (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:19452630 PMID:20567778 PMID:25367288 PMID:28611668 PMID:29988851 PMID:30689673
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