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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcrdecreases expressionEXP 6480464CTDCurcumin results in decreased expression of HMGCR mRNAPMID:27208389
Hmgcraffects expressionISOHmgcr (Mus musculus)6480464CTDCurcumin affects the expression of HMGCR mRNA; Curcumin affects the expression of HMGCR proteinPMID:27208389
Hmgcrincreases expressionISOHMGCR (Homo sapiens)6480464CTDCurcumin results in increased expression of HMGCR mRNAPMID:16713233
Hmgcrmultiple interactionsISOHmgcr (Mus musculus)6480464CTDCurcumin inhibits the reaction [bisphenol A results in increased expression of HMGCR protein]PMID:37701206
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