GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1b1 | increases expression | EXP | | 6480464 | CTD | benz(a)anthracene results in increased expression of CYP1B1 mRNA; benz(a)anthracene results in increased expression of CYP1B1 protein | PMID:18205319 PMID:21384493 PMID:23358148 PMID:8674863 | Cyp1b1 | multiple interactions | EXP | | 6480464 | CTD | [benz(a)anthracene co-treated with benzo(b)fluoranthene] promotes the reaction [chrysene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]; [chrysene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; [chrysene co-treated with benz(a)anthracene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene] results in increased expression of CYP1B1 mRNA; [Estradiol co-treated with Progesterone co-treated with Hydrocortisone co-treated with PRL protein] inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 protein]; Hydrocortisone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]; Hydrocortisone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 protein]; Progesterone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 protein] | PMID:37189300 PMID:8674863 | Cyp1b1 | increases expression | ISO | Cyp1b1 (Mus musculus) | 6480464 | CTD | benz(a)anthracene results in increased expression of CYP1B1 mRNA; benz(a)anthracene results in increased expression of CYP1B1 protein | PMID:10497882 PMID:12117779 PMID:17825862 PMID:26377693 PMID:7505439 PMID:8022408 | Cyp1b1 | increases expression | ISO | CYP1B1 (Homo sapiens) | 6480464 | CTD | benz(a)anthracene results in increased expression of CYP1B1 mRNA; benz(a)anthracene results in increased expression of CYP1B1 protein | PMID:12224597 PMID:12520072 PMID:17253728 PMID:19358281 PMID:22236718 PMID:23396138 PMID:27196671 PMID:32890658 PMID:9783729 | Cyp1b1 | increases stability | ISO | Cyp1b1 (Mus musculus) | 6480464 | CTD | benz(a)anthracene results in increased stability of CYP1B1 protein | PMID:8022408 | Cyp1b1 | multiple interactions | ISO | Cyp1b1 (Mus musculus) | 6480464 | CTD | [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1B1 mRNA; [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CYP1B1 mRNA; benz(a)anthracene promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]; Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA] | PMID:10037446 PMID:10497882 PMID:17825862 PMID:27858113 | Cyp1b1 | multiple interactions | ISO | CYP1B1 (Homo sapiens) | 6480464 | CTD | [benz(a)anthracene co-treated with TNF protein] results in increased expression of CYP1B1 mRNA; AHR protein affects the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA] | PMID:12224597 PMID:23396138 | | ||||||||||||||||||||||
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