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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2092
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B1
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b1affects reductionISOAKR1B1 (Homo sapiens)6480464CTDAKR1B1 protein affects the reduction of 4-hydroxy-2-nonenalPMID:11306073
Akr1b1increases reductionISOAKR1B1 (Homo sapiens)6480464CTDAKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal; AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolitePMID:10510318 PMID:21329684 PMID:9890881
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