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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:4948
Term: Evodiamine
Definition: A beta-carboline that has formula C19H17N3O.
Chemical ID: MESH:C049639
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDevodiamine results in increased cleavage of PARP1 proteinPMID:34808100
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDEUK-134 inhibits the reaction [evodiamine results in increased cleavage of PARP1 protein]; evodiamine promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]; Rotenone inhibits the reaction [evodiamine results in increased cleavage of PARP1 protein]PMID:15710601 PMID:34808100
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