GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | decreases activity | ISO | Parp1 (Mus musculus) | 6480464 | CTD | 4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein | PMID:16556909 | Parp1 | decreases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | 4-amino-1,8-naphthalimide results in decreased expression of PARP1 protein | PMID:25499136 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | 4-amino-1,8-naphthalimide inhibits the reaction [Doxorubicin results in increased activity of PARP1 protein] | PMID:15456408 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | ATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein]; PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein] | PMID:16556909 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |