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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1affects expressionEXP 6480464CTDbisphenol A affects the expression of PARP1 mRNAPMID:25181051
Parp1decreases cleavageEXP 6480464CTDbisphenol A results in decreased cleavage of PARP1 proteinPMID:24884420
Parp1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PARP1 mRNA; bisphenol A results in decreased expression of PARP1 proteinPMID:27189055 PMID:34947998
Parp1increases cleavageEXP 6480464CTDbisphenol A results in increased cleavage of PARP1 proteinPMID:35567931 PMID:35887390
Parp1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of PARP1 genePMID:28505145
Parp1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with tributyltin] results in increased expression of PARP1 mRNA; Genistein inhibits the reaction [bisphenol A results in decreased cleavage of PARP1 protein]PMID:24884420 PMID:31129395
Parp1affects expressionISOPARP1 (Homo sapiens)6480464CTDbisphenol A affects the expression of PARP1 mRNAPMID:30903817
Parp1decreases expressionISOPARP1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of PARP1 mRNA; bisphenol A results in decreased expression of PARP1 proteinPMID:29275510 PMID:31675489 PMID:37567409
Parp1increases expressionISOPARP1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of PARP1 proteinPMID:34186270
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTDbisphenol A promotes the reaction [Cholesterol results in increased cleavage of PARP1 protein]; Resveratrol inhibits the reaction [bisphenol A promotes the reaction [Cholesterol results in increased cleavage of PARP1 protein]]PMID:33239236
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