GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | affects expression | EXP | | 6480464 | CTD | bisphenol A affects the expression of PARP1 mRNA | PMID:25181051 | Parp1 | decreases cleavage | EXP | | 6480464 | CTD | bisphenol A results in decreased cleavage of PARP1 protein | PMID:24884420 | Parp1 | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of PARP1 mRNA; bisphenol A results in decreased expression of PARP1 protein | PMID:27189055 PMID:34947998 | Parp1 | increases cleavage | EXP | | 6480464 | CTD | bisphenol A results in increased cleavage of PARP1 protein | PMID:35567931 PMID:35887390 | Parp1 | increases methylation | EXP | | 6480464 | CTD | bisphenol A results in increased methylation of PARP1 gene | PMID:28505145 | Parp1 | multiple interactions | EXP | | 6480464 | CTD | [bisphenol A co-treated with tributyltin] results in increased expression of PARP1 mRNA; Genistein inhibits the reaction [bisphenol A results in decreased cleavage of PARP1 protein] | PMID:24884420 PMID:31129395 | Parp1 | affects expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | bisphenol A affects the expression of PARP1 mRNA | PMID:30903817 | Parp1 | decreases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of PARP1 mRNA; bisphenol A results in decreased expression of PARP1 protein | PMID:29275510 PMID:31675489 PMID:37567409 | Parp1 | increases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased expression of PARP1 protein | PMID:34186270 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | bisphenol A promotes the reaction [Cholesterol results in increased cleavage of PARP1 protein]; Resveratrol inhibits the reaction [bisphenol A promotes the reaction [Cholesterol results in increased cleavage of PARP1 protein]] | PMID:33239236 | |
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