GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | multiple interactions | EXP | | 6480464 | CTD | Quercetin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; Quercetin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased cleavage of PARP1 protein]; Quercetin inhibits the reaction [Glucose results in increased cleavage of PARP1 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] | PMID:14505808 PMID:22524206 PMID:23138875 PMID:24316378 PMID:24902966 | Parp1 | decreases activity | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Quercetin results in decreased activity of PARP1 protein | PMID:17884996 | Parp1 | decreases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Quercetin results in decreased expression of PARP1 mRNA | PMID:20596804 PMID:30152185 | Parp1 | decreases expression | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Quercetin results in decreased expression of PARP1 protein | PMID:17039455 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Quercetin metabolite results in increased cleavage of PARP1 protein; Quercetin results in increased cleavage of PARP1 protein | PMID:12168845 PMID:12874837 PMID:14688022 PMID:15741050 PMID:18455702 PMID:18787224 PMID:19138980 PMID:20096292 PMID:20386985 PMID:20438634 PMID:20658310 PMID:21165570 PMID:21732360 PMID:22555976 PMID:23094058 PMID:23727915 PMID:23918355 PMID:24275163 PMID:24647664 PMID:25830055 PMID:25896339 PMID:27175602 PMID:28251795 | Parp1 | increases cleavage | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Quercetin results in increased cleavage of PARP1 protein | PMID:26076811 | Parp1 | increases degradation | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Quercetin results in increased degradation of PARP1 protein | PMID:16059641 | Parp1 | increases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Quercetin metabolite results in increased expression of PARP1 protein; Quercetin results in increased expression of PARP1 protein modified form | PMID:16280456 PMID:19017364 PMID:28251795 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; [ABCB1 protein results in decreased susceptibility to Doxorubicin] inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; [BAX protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein; [ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein; [ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein; [Quercetin co-treated with hyperoside] results in increased cleavage of PARP1 protein; [Resveratrol co-treated with Quercetin] results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with Quercetin] results in increased cleavage of PARP1 protein; AKT1 protein inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Quercetin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; DDIT3 protein affects the reaction [[TNFSF10 protein co-treated with Quercetin] results in increased cleavage of PARP1 protein]; Fulvestrant inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; NFE2L2 protein inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; Quercetin inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of PARP1 protein]; Quercetin inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of PARP1 protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]; Quercetin promotes the reaction [manumycin results in increased cleavage of PARP1 protein]; Quercetin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [[ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein] | PMID:14625852 PMID:14688022 PMID:17548900 PMID:17876056 PMID:18377872 PMID:18455702 PMID:19194971 PMID:20096292 PMID:20386985 PMID:20438634 PMID:21165570 PMID:21732360 PMID:22002103 PMID:23530649 PMID:24173369 PMID:24612139 PMID:25354548 PMID:25896339 PMID:27050144 PMID:28251795 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Quercetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] | PMID:15876423 | | ||||||||||||||||||||||
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