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GENE - TERM ANNOTATION REPORT

RGD ID: 18913436
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8 ISOCASP8 (Homo sapiens)9068941RGD PMID:12633148 PMID:16772874 REF_RGD_ID:13782268 REF_RGD_ID:13782269
Casp8treatmentISOCasp8 (Rattus norvegicus)9068941RGD PMID:29642617 REF_RGD_ID:13782291
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