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GENE - TERM ANNOTATION REPORT

RGD ID: 1621218
Species: Mus musculus
RGD Object: Gene
Symbol: Fan1
Name: FANCD2/FANCI-associated nuclease 1
Acc ID: GO:0036297
Term: interstrand cross-link repair
Definition: Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
Definition Source(s): GOC:vw, PMID:16464006, PMID:22064477
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fan1involved_inIBAPANTHER:PTN000405526 or TAIR:locus:2007740 or PomBase:SPBC146.06c or UniProtKB:Q9Y2M02290270GO_Central GO_REF:0000033
Fan1involved_inISOUniProtKB:Q9Y2M02290270MGI GO_REF:0000119 MGI:4834177
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