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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1549774
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irf3
Name: interferon regulatory factor 3
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irf3multiple interactionsISOIrf3 (Mus musculus)6480464CTDhydroquinone inhibits the reaction [AKT1 protein results in increased phosphorylation of IRF3 protein]; hydroquinone inhibits the reaction [AKT2 protein results in increased phosphorylation of IRF3 protein]; hydroquinone inhibits the reaction [AKT3 protein results in increased phosphorylation of IRF3 protein]; hydroquinone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRF3 protein]; hydroquinone inhibits the reaction [TICAM1 protein results in increased phosphorylation of IRF3 protein]PMID:28883758
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