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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318106
Species: Homo sapiens
RGD Object: Gene
Symbol: SIRT3
Name: sirtuin 3
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SIRT3decreases expressionEXP 6480464CTDresveratrol results in decreased expression of SIRT3 mRNAPMID:21980390
SIRT3increases activityEXP 6480464CTDresveratrol results in increased activity of SIRT3 proteinPMID:24178296
SIRT3increases expressionEXP 6480464CTDresveratrol results in increased expression of SIRT3 mRNAPMID:25522270
SIRT3multiple interactionsEXP 6480464CTDPPARGC1A mutant form inhibits the reaction [resveratrol results in increased expression of SIRT3 mRNA]; PPARGC1A mutant form inhibits the reaction [resveratrol results in increased expression of SIRT3 protein]; resveratrol affects the localization of and results in increased expression of SIRT3 protein; SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of and results in increased acetylation of SOD2 protein]]; SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]]; SIRT3 protein affects the reaction [resveratrol results in decreased acetylation of CYP11A1 protein]; SIRT3 protein affects the reaction [resveratrol results in increased expression of CYP11A1 protein]PMID:22585829 PMID:25522270
SIRT3decreases expressionISOSirt3 (Mus musculus)6480464CTDresveratrol results in decreased expression of SIRT3 mRNAPMID:23525482
SIRT3multiple interactionsISOSirt3 (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 protein]; resveratrol inhibits the reaction [Ethanol results in increased expression of SIRT3 mRNA]PMID:18793633 PMID:25686565
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