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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpldecreases methylationISOMPL (Homo sapiens)6480464CTDhydroquinone results in decreased methylation of MPL genePMID:22245671
Mplincreases expressionISOMPL (Homo sapiens)6480464CTDhydroquinone results in increased expression of MPL mRNAPMID:22245671
Mplmultiple interactionsISOMPL (Homo sapiens)6480464CTD[trichostatin A co-treated with Decitabine] promotes the reaction [hydroquinone results in increased expression of MPL mRNA]; Decitabine promotes the reaction [hydroquinone results in increased expression of MPL mRNA]PMID:22245671
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